牛珀至宝丹对内毒素休克大鼠血浆肿瘤坏死因子—α和血清转氨酶活性的影响

Influence of Niupozhibaodan on Plasmal Tumor Necrotic Factor - α and Activity . of Serum Transaminase in Rats in Shock State Induced by Endotoxin

采用一次性静脉注射致死量灭活大肠杆菌内毒素造成大鼠重症感染性休克模型,以牛珀至宝丹预先给实验组动物灌胃,并与正常组、内毒素休克组进行对照,结果:内毒素休克组大鼠血浆肿瘤坏死因子—α(TNF—α)、血清ALT及AST含量较正常组显著增高,而经牛珀至宝丹预处理的实验组,其升高程度较休克组明显减轻,组间比较,差异均有非常显著性(P<0.01)。表明牛珀至宝丹能明显抑制TNF—α的释放和ALT、AST的活性,这可能是其抗休克的重要机理之一。

Ma Chaoying, Geng Yun, Peng Rencai, et al Shock rat models were made by injecting a one lethal dose E - coli deactivated endotoxin to cause serious infectious shock. For the treatment group. Niupozhibaodan was administered in advance, which was compared with normal group and endotoxin -shock group. Results show that, in the endotoxin group, the plasma TNF - α . serum ALT and AST contents were all markedly higher, while in the experimental group, the increase of the indexes was markedly lower than the shock - group, all with significant difference.