轻度认知障碍患者视空间工作记忆的变化

Change of visuospatial working memory in patients with mild cognitive impairment

目的探索轻度认知障碍(MCI)患者视空间工作记忆的广度和准确度的变化。方法根据临床记忆检查和Blessed-Roth生活评定结果诊断的MCI患者20例和与之匹配的正常对照20例进行扫视记忆和重现数字位置的试验。结果 MCI组扫视记忆的正确率比对照组下降,差异有统计学意义(P<0.05)。扫视的平均速度与对照组的差异无统计学意义(P>0.05)。两组能正确记忆位置的数字个数差异无统计学意义(P>0.05),为达到最好的记忆效果,MCI组需要数字呈现的时间比对照组长,差异有统计学意义(P<0.05)。结论 MCI患者视觉空间工作记忆的中央执行系统运转正常,视空间模板的存贮空间保留,视空间工作记忆的广度正常,而视空间初步加工系统中两种次级记忆的准确性下降,导致视空间工作记忆的准确度下降。

Objective To detect the change of visuospatial working memory on span and accuracy in patients with mild cognitive impairment （MCI）.Methods 20 MCI patients diagnosed by the scores of clinical memory test and Blessed-Roth daily life assessment,and 20 matched normal controls took saccade memory test and filled in the disappeared digits in the right places.Results MCI patients had a lower accurate ratio than controls in saccade memory test and the difference was of significance （P0.05）.The velocities of saccade was not significant （P0.05）.The amounts of correct numeric location recurred between the two groups had no significant difference （P0.05）.MCI patients needed longer time to show the digits for the best encoding effect than controls and the difference was statistically significant （P0.05）.Conclusion In MCI patients,the central executive system of visuospatial working memory dose work and the capacity of visuospatial sketchpad is preserved,but the accuracy of the sub-memories＇ primary process in the visuospatial sketchpad decreased,so that MCI patient＇s visuospatial working memory has declined accuracy and normal span.