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PHA-767491联合IL-24基因对肝癌细胞的杀伤研究 被引量：2

Study of the Anti-Tumor Efficacy by PHA-767491 Combined with IL-24 in Hepatocellular Carcinoma Cells
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摘要 利用最新发现的抗癌新药PHA-767491联合肿瘤基因治疗中最常用的杀伤基因IL-24共同处理肝癌细胞Bel-7404,采用20MOI携带IL-24基因的非复制型病毒Ad-IL-24联合不同浓度的PHA-767491对肝癌细胞Bel-7404进行治疗研究。western blot实验结果表明:PHA-767491对IL-24的表达无明显抑制作用;MTT和Ho-ceast33342染色实验表明二者联合对Bel-7404细胞表现出了较高协同杀伤作用。 New anti-tumor medicine PHA-767491 is used to kill tumor cells combined with IL-24.Here the authors demonstrate that 20 MOI of replication deficient recombinant adenovirus armed with IL-24（Ad-IL-24） has remarkable efficacy against tumor cells Bel-7404 in combination with PHA-767491 in a series of concentrations.PHA-767491 doesn＇t influence the expression of IL-24 by western blot when PHA-767491 combines with Ad-IL-24 in Bel-7404.
作者 李伟 张静 骆菁菁 胡徐庞 杨耿兵 王刚 娄文加 钱程 刘立
机构地区 浙江理工大学生命科学学院
出处 《浙江理工大学学报（自然科学版）》 2010年第4期641-644,共4页 Journal of Zhejiang Sci-Tech University(Natural Sciences)
基金 973计划(2004CB518804)
关键词 PHA-767491 IL-24 BEL-7404 PHA-767491 IL-24 Bel-7404
分类号 Q786 [生物学—分子生物学]
  • 相关文献

参考文献11

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二级参考文献34

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共引文献4

同被引文献10

  • 1Montagnoli A, Valsasina B, Croci V, et al. A CAc7 kinase inhibitor restricts initiation o{ DNA replication and has anti- tumor activity[J]. Nat Chem Biol, 2008, 4(6) .. 357-365.
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  • 6Montagnoli Alessia,Valsasina Barbara,Croci Valter,Menichincheri Maria,Rainoldi Sonia,Marchesi Vanessa,Tibolla Marcello,Tenca Pierluigi,Brotherton Deborah,Albanese Clara,Patton Veronica,Alzani Rachele,Ciavolella Antonella,Sola Francesco,Molin.A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nature chemical biology . 2008
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  • 9李伟,田雪君,刘立,钱程.huCdc7激酶及其与肿瘤的关系[J].生物化学与生物物理进展,2009,36(7):810-816. 被引量：5
  • 10李伟,张静,胡徐庞,魏旭斌,刘立,钱程.PHA-767491抑制多种肿瘤细胞生长[J].中国生物化学与分子生物学报,2010,26(5):455-461. 被引量：5

引证文献2

二级引证文献3

浙江理工大学学报（自然科学版）
2010年 第4期

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