摘要
目的:对丹参和刺五加注射液的混合液(以下简称刺丹混合液)进行抗心肌缺血作用的研究,以证实丹参与刺五加合并用药是否存在有效性、协同性以及筛选出二者合用抗心肌缺血的最佳配伍比例。方法:采用大鼠离体心脏langendorff灌流实验方法,通过均匀设计方法安排试验,筛选出刺丹混合液的最佳处方组成。结果:刺丹混合液能显著增加冠脉流量,效果大于刺五加注射液和丹参注射液组,具有增强心肌收缩幅度作用。结论:刺丹混合液疗效优于丹参注射液和刺五加注射液。且刺丹混合液药效最佳配比为刺五加注射液(以紫丁香苷含量计):丹参注射液(以原儿茶醛含量计)=1:1.35(相当于生药量配比刺五加:丹参=1.25:1)。
Objective：This article is to carry out the study on Salvia mihiorrhiza injection and acanthopanax senticosus injection mixture （CIDAN mixture for short）against myocardial ischemia, and to filter out the best prescription composition of CIDAN mixture through the uniformity experiment design. Method： Apply the way of perfusion experiment on the isolated heart of rat to filter out the best prescription composition of CIDAN mixture through the uniformity experiment design. Result：The mixture , as well as enhance the shrinking range of cardiac muscle, can much more significantly increase the blood flow of coronary artery than that of one of the mixture. Conclusion： The best prescription composition of CIDAN mixture is aeathopanax injection （the content of syringoside） lvia miltiorrhiza injection （ （ the content of protocateehualdehyde） = 1/1.35 （ correspond dosage of crude drug = 1.25/1 ）.
出处
《中医药信息》
2010年第4期75-78,共4页
Information on Traditional Chinese Medicine
基金
黑龙江省科技计划项目(GC06C32802)
关键词
丹参注射液
刺五加注射液
均匀设计
心肌缺血
Salvia miltiorrhiza injection
acanthopanax injection
uniform design
myocardial ischemia
