Gwe治疗对慢性肝炎患者血清补体溶解免疫复合物能力的影响

Effects of Gwe on the serum complement mediated immune complex solubilizing capacity in chronic persistent hepatitis patients

目的：探讨Ｇｗｅ口服液对慢性迁延型肝炎患者血清补体溶解免疫复合物能力（ＣＭＳＣ）的影响。方法：以健康献血员为对照，采用改良的天野氏比色法，测定１８例慢性迁延型肝炎患者服用Ｇｗｅ前后１个月左右的ＣＭＳＣ。结果：患者的ＣＭＳＣ下降为８４．３％（Ｐ＝０．０２），经Ｇｗｅ治疗后恢复正常。血清Ｃ３含量与其ＣＭＳＣ水平呈显著正相关（ｒ＝０．９２２，Ｐ＜０．０１），血清ＣＭＳＣ与Ｃ４之间无显著相关性。结论：Ｇｗｅ治疗后ＣＭＳＣ活性显著升高，有利于减少免疫复合物的沉积，阻断慢性肝炎的病理进程。

Objective:To discuss the effect of Gwe on the serum complement mediated immune complex solubilizing capacity in chronic persistent hepatitis patients.Methods:Serum complement mediated immune complex solubilizing (CMSC)was measured in 18 chronic persistent hepatitis (CPH) patients and in 10 normal individuals.Results:It was found that the level of serum CMSC in the CPH patients was significantly lower than that in normal individuals(P=0.02),and was significantly increased after treating with Gwe for a month.There was a positive relationship between the CMSC and serum C3 level in 18 patients,while the relationship of the CMSC with serum C4 was not found.Conclusion:The increased activity of CMSC after Gwe treatment is helpful to clean the deposited immune complex,and to discontinue the progress of chronic hepatitis.