实验性消化道溃疡上皮淋巴细胞毒活性的变化

The change of cytotoxicity of intestinal intraepithelial lymphocytes from mice with experimental digestive ulcer

目的：了解消化道溃疡机体的免疫功能变化。方法：应用生物学测定法检测了水浸限制刺激诱发的Ｃ５７ＢＬ／６小鼠消化道溃疡动物模型肠上皮淋巴细胞和脾淋巴细胞的细胞毒活性的变化。结果：发现给予水浸限制刺激后第２天，小鼠肠上皮淋巴细胞对靶细胞的杀伤活性增至最高，达５２．３％，１ｗ后基本恢复正常水平。脾淋巴细胞的杀伤活性在水浸限制刺激后第５天明显下降，第９天仍未完全恢复至正常水平。结论：肠上皮淋巴细胞活性在消化道溃疡发生后的一定期间内有升高。

Objective:In order to understand immunological changes in the body with digestive ulcer.Methods:The cytotoxity of intestinal intraepithelial lymphocytes(IELs)in C57BL/6 mice with digestive ulcer induced by water immersion were examined by biological assay technique.Results:It was showed that the cytotoxity of IELs was enhanced to a peak in 2 days and down back to the normal in 7 days after the stress and that the cytotoxity of spleen cells was lower than that of normal and could not revive to normal level on the 9th day. Conclusion:the cytotoxity of IELs was increased in a certain period of time after the ulcer,indicating IELs may play a protective role in digestive tract.