孕妇及妊娠高血压综合征患者血浆蛋白C及游离蛋白S水平的变化

Changes of Plasma Levels of Protein C and Free Protein S in Normal Women and Patients With Pregnancy Induced Hypertension

目的探讨正常孕妇及妊娠高血压综合征（简称妊高征）患者血浆蛋白Ｃ和游离蛋白Ｓ水平改变及意义。方法采用生色法测定血浆蛋白Ｃ，免疫比浊法测定血浆游离蛋白Ｓ。受试者分为三组：妊高征组（组１），３３例；正常妊娠组（组２），３３例；正常非妊娠组（组３），３３例。结果组２和组３血浆蛋白Ｃ水平无显著差异（Ｐ＞００５），组１血浆蛋白Ｃ水平分别低于组２（Ｐ＜００１）和组３（Ｐ＜００１）。组２血浆游离蛋白Ｓ水平低于组３（Ｐ＜００１），组１血浆游离蛋白Ｓ水平与组２无显著差异（Ｐ＞００５），但低于组３（Ｐ＜００１）。结论正常孕妇单纯游离蛋白Ｓ水平下降，不足以发生高凝状态；妊高征患者血浆游离蛋白Ｓ水平与蛋白Ｃ水平均下降，则可能导致高凝状态。

Objective\ To investigate the changes of plasma levels of protein C and free protein S in normal pregnant women and patients with pregnancy induced hypertension (PIH) and to evaluate the significance of these changes. Methods\ Plasma levels of protein C and free protein S were measured by means of synthetic chromogenic substrate assay and microlatex particle-mediated immunoassay, respectively. Three groups of women were studied:33 women with PIH were in group 1, 33 normal pregnant women in group 2, and 33 nonpregnant women in group 3. Results\ There was no significant difference in plasma protein C levels between group2 and group 3 (p>0.05), but the plasma protein C level in group 1 was obviously lower than that in group 2 (p<0.01) and group 3 (p<0.01). The plasma level of free protein S in group 2 was significantly lower than that in group 3 ( P <0.01). Its level in group 1 was similar to that in group 2 ( P >0.05), but was markedly lower than that in group 3 ( P <0.01). Conclusions\ The decreased plasma free protein S level did not lead to hypercoagulable states in normal pregnant women. But the simultaneously decreased plasma levels of protein C and free protein S might cause hypercoagulable states in PIH.