非典型尖锐湿疣HPV-DNA分型与临床病理分析

HPV-DNA Types of Atypical Condyloma Acuminata and Clinicopathologic Analysis

目的探讨非典型尖锐湿疣病例乳头状瘤病毒（ＨＰＶ）感染及其临床病理特点。方法采用ＰＣＲ法检测了４０例临床疑诊为ＨＰＶ感染患者外阴湿疣组织中ＨＰＶ－ＤＮＡ类型。结果在４０例临床疑诊为尖锐湿疣的患者中，经组织病理学检查，９例确诊为尖锐湿疣；３１例为非典型尖锐湿疣，其上皮细胞轻度增生，挖空细胞不典型或无。ＨＰＶ６型阳性１３例（占４１９４％），ＨＰＶ１１型阳性１４例（占４５１６％），ＨＰＶ１６和１８型阳性５例（占１６１３％），合并淋球菌感染９例。结论非典型尖锐湿疣存在不同类型的ＨＰＶ感染，以ＨＰＶ６、１１型感染为主。ＨＰＶ－ＤＮＡ的检测有助于正确判断尖锐湿疣和假性尖锐湿疣。

Objective\ To investigate the infection of human papilloma virus(HPV)in atypical condyloma acuminata and its clinicopathologic characteristics. Methods\ HPV-DNA types of 6,11, and 16/18 were detected in vulvar lesion of 40 suspect patients using PCR method. Results\ 31 patients were diagnosed as atypical condyloma acuminata by histopathological examination. Slight hyperplasia was found in epithelial cells of vulvar lesions, but no koilocytosis or only atypical one were obserued. 13 cases were positive for HPV 6 (41.9%), 14 positive for HPV 11 (45.16%), 5 positive for HPV16/18 (16.13%). Among them, 9 patients had gonococci infection. Conclusions\ Some cases of atypical condyloma acuminata have different types of HPV infection, mainly HPV 6 and 11. Detection of HPV-DNA types by PCR technique was helpful in distinguish between true and false condyloma acuminata.