初诊2型糖尿病血糖控制与C反应蛋白相关性探讨

STUDY ON THE RELATIONSHIP BETWEEN BLOOD GLUCOSE CONTROL AND SERUM C-REACTIVE PROTEIN LEVEL IN NEWLY ONSET PATIENTS WITH NIDDM

目的探讨2型糖尿病患者血糖控制与血清c反应蛋白（CRP）变化的相关性。方法选初诊断为T2DM患者90倒，另选同时期在我院体检的健康人群90人作为对照纽，并按性别、年龄、体重与实验纽进行对照匹配，治疗前后检查治疗组与对照组的身高、体重，空腹血糖（FPG）、空腹胰岛素（Fins）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）、糖化血红蛋白（HbAlc）以及C反应蛋白（CRP）。结果治疗前治疗组CRP明显高于对照组；治疗后治疗组CRP与对照组无明显差异。CRP水平与血糖水平呈正相关。结论2型糖尿病的发生与发展可能与机体的慢性炎症反应相关，部分体现在血清CRP的升高，在今后对2型糖尿病的诊治中要密切关注患者血清CRP的水平，早期使用胰岛素治疗可能有助于减轻炎症反应，延缓病程。

Objective To investigate the relationship between blood glucose control and the change of serum C - reactive protein （CRP） in patients with NIDDM. Methods 90 newly onset NIDDM patients in our hospital were chosen to be control group and 90 health peoples were assigned to be contrast group matched by gender, age and body weight. The body height, body weight, fasting plasma glucose （FPG）, fasting insulin （Fins）, total cholesterol （TC）, triglycefide （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL）, glycosylated hemoglobin （HbAlc）, and C -reactive protein （CRP） were detected. Resttlts The level of CRP in the control group was sig- nificantly higher than that in the contrast group pretherapy. There was no noticeable difference in CRP level between two groups post - treatment. The level of CRP in NIDDM patients was positive correlated with blood glucose. Conclu- sion The nosogenesis of NIDDM may be related to the chronic inflammatory reaction with high serum CRP level. We should pay close attention to the change of serum CRP level in patients with NIDDM during the treatment, and the early application of insulin may be helpful to reduce inflammatory reaction and delay the course of NIDDM.