兔眼窝内羟基磷灰石义眼台血管化过程的组织病理学观察

A histopathologic observation on the vascularization of hydroxyapatite implants in the sockets of rabbits

目的：观察羟基磷灰石义眼台眼窝内植入术后血管化过程的组织病理学改变。方法：用１７只新西兰种兔分２组。Ａ组（７只）行眼球摘除眼窝内羟基磷灰石植入术；Ｂ组（１０只）行眼内容剜出自体巩膜覆盖羟基磷灰石植入术。观察２组术后第１，２，３，４，６周和第２，３，４，５，６月的大体标本形态和义眼台血管化过程中的组织病理学变化。结果：Ａ组，１周时义眼台表面孔隙内即有纤维结缔组织生长，４周时伸入义眼台中心部分孔隙内，２月后组织成熟，完全血管化；Ｂ组，术后第３周时自体巩膜与义眼台贴敷紧密，邻接的孔隙内开始有纤维结缔组织生长，２月时伸入义眼台的中心部分孔隙内，３月后组织成熟，完全血管化。结论：羟基磷灰石义眼台与眼眶组织接触面积越大其完全血管化速率越快。

Aim: To observe histopathologic changes of the vascularization after placement of an orbital hydroxyapatite implant in rabbits. Methods: 17 rabbits were divided into 2 groups: group A and group B.Group A (7 rabbits) received enucleations of eyeballs and hydroxyapatite implants; group B ( 10 rabbits) received evisceration and hydroxyapatite implants covered with autoseleras.The animals were inspected for a postoperative general conditions and the histophathologic changes of the vascularization in two groups at 1,2,3,4 and 6 weeks,and 2,3,4,5 and 6 months. Results: In group A, limited fibrovascular ingrowth appeard in the surface of implants at 1 week,limited fibrovascular ingrowth penetrated into the center of implants at 4 weeks, and completion of vascularization was ascertained at 2 months; In group B, autoscleras adhered implants closely and limited fibrovascular ingrowth into the implants appeared at 3 weeks, limited fibrovascular ingrowth penetrated into the center of implants at 2 monthes and completion of the vascularization was ascertained at 3 months. Conclusion: The larger area of hydroxyapatite implants contacting tissue of intraorbital is, the faster completion of the vascularizationis.