白细胞介素-6mRNA在脑肿瘤的表达及其意义

Significance of interleukin 6 mRNA Expression in Brain Tumors

探讨ＩＬ－６与不同类型脑肿瘤的相关性。方法：采用地高辛标记ＩＬ－６ｃＤＮＡ探针，运用原位杂交技术检测ＩＬ－６ｍＲＮＡ在４０例脑肿瘤组织中的表达。结果：在良、恶性肿瘤组表达率分别为２３．１％、７０．４％，恶性肿瘤组明显高于良性组，两组差异非常显著（Ｐ＜０．０１）．星形细胞瘤低分化组表达率大子高分化组，两组差异显著（Ｐ＜０．０５）。结论：结果表明ＩＬ－６ｍＲＮＡ表达率与肿瘤性质及星形细胞瘤的病理分级有关。提示ＩＬ－６可能对胶质细胞瘤的生长增殖有促进作用，对高分化的星形细胞瘤进一步向恶性发展可能有关系，测定血清ＩＬ－６对恶性肿瘤的预后判断有一定意义。

Objective: To evaluate the significance of IL - 6 mRNA expression in various kinds ofbrain tumors. Methods: Digoxin - labelled IL - 6 DNA probe was used to detect the expression of IL -6 mRNA by in situ hybridization in 40 cases of various brain tumors. Results: The expression rates in be-nign and malignant tumors were 23.1 % and 70. 4% respectively, being much lower in benign tumors com-pared with malignant tumors (P<0.01) . In poorly differentiated astrocytoma however, IL - 6 mRNAwas much higher than in well differentiated astrocytomas (P<0.05) . Conclusion: The expression ofIL - 6 mRNA is associated with the nature of the brain tumor and the pathological grade in the case of astro-cytoma. Hence, IL - 6 might play an important role in proliferation and development of glioma and deterio-ration of highly differentiated astrocytoma. Therefore, detection of serum IL - 6 is of significance in theproguosis of malignant brain tumors.