胰腺癌中雌激素受体表达与其生物学特性的研究

Estropen receptor expression in the pancreatic carcinoma and its clinical implication

探讨胰腺癌中雌激素受体（ＥＲ）的表达及与其生物学特性的关系。方法观察２４例胰腺癌切除标本的ＥＲ表达（Ｓ－Ｐ免疫组化染色法）与肿瘤大小、有无血管浸润、淋巴转移关系，并以正常胰腺组织标本作为对照。结果２４例胰腺癌病人ＥＲ阳性１４例（５８．３％），１２例正常胰腺中仅有１例为ＥＲ阳性（８３％）。胰腺癌的ＥＲ表达明显高于正常胰腺组织（Ｐ＜０．０１）。其中肿瘤越大其阳性表达越低，＞５ｃｍ者ＥＲ阳性率明显低于≤５ｃｍ者（Ｐ＜０．０５）。高分化胰腺癌中ＥＲ阳性率明显高于低分化者，两者之比为８３．３３％：３３．３％，Ｐ＜０．０５。ＥＲ阳性者的血管侵犯率明显低于ＥＲ阴性者（Ｐ＜０．０５）。ＥＲ阳性的胰腺癌转移率低于ＥＲ阴性者，但两者差异无显著意义（Ｐ＞０．０５）。结论胰腺癌组织中ＥＲ有较高的表达率（５３．３％）。ＥＲ的表达与肿瘤的大小、细胞分化程度、血管浸润等生物学特性相关，ＥＲ阳性者多有较好的生物学特性。

Objective To elucidate estrogen receptor (ER) expression in the pancreatic carcinoma andits clinical implication. Method Twenty-four surgical specimens of the pancreatic carcinoma and 12 specimensof normal pancreas were investigated by using immunohistochemical technique (S-P method). Result Thepositive rate of ER in the pancreatic carcinoma cases was 58.3%, which was much higher than in the normalpancreas (8.3%) with the difference being significant (P<0.01). The ER was more highly expressed inthe smaller and better-differentiated pancreatic carcinoma than that in the large and poor differentiated one.The ER positive tumor was more possibility to invade vessels than the ER negative one (P<0.05 for all).Conclusion ER can be highly expressed in the pancreatic carcinoma cells, and its expression is related to itsbiological behaviors such as differentiation, vessel invasion, tumor size, etc.. Endocrine therapy is an adjuvantway to treat pancreatic carcinoma with positive ER expressed.