氯胺酮治疗颌面部撞击致颅脑损伤的动物实验研究

Animal Experiment of the Ketamine Effects on Traumatic Brain Injury Resulting from Impact Maxillofacial Injury

目的：探索临床应用氯胺酮对颌面部撞击致颅脑损伤早期治疗的可能性。方法：采用落体撞击大鼠颌面部发生中等程度的创伤性脑损伤动物模型，给予氯胺酮进行早期药物治疗，观察大鼠神经功能的恢复时间。结果：氯胺酮治疗组大鼠在木条平衡和木条行走实验中与对照组相比差别明...

Objective:To test the effects of ketamine (KET) on traumatic brain injury resulting from impact maxillofacial injury. Methods: The rat models with middle serious traumatic brain injury were obtained by falling impaction at maxillofacial region of the rats, then the animals were treated with KET in the early stage, and the alteration of the neural function in those rats was observed at the same time. Results: There was obvious difference between the rats in the KET treating groups and the control group. It took about 2 days fewer than that of the control group for rats in the KET treating group to recover. Conclusion: KET can shorten the recovery time of rats with brain injury resulting from impact maxillofacial injury.