摘要
目的:观察甜梦胶囊对更年期综合征失眠患者PSQI5项分值与性激素的影响。方法:①患者于晚饭前和临睡前各服甜梦胶囊3粒,疗程12周,采用匹兹堡睡眠质量指数(PSQI)量表对治疗前后进行效果评分;②以放射免疫分析法测定两组治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)及雌二醇(E2)水平并进行统计学比较;结果:甜梦胶囊治疗后PSQI总分值、睡眠时间、睡眠质量及日间功能障碍分值等均较治疗前明显改善(P<0.05和P<0.01);可显著降低轻、中度病人Kupperman分值水平(P<0.05);对性激素水平虽有轻度变化,但无统计学意义;结论:甜梦胶囊在改善更年期综合征轻中度失眠症状方面具有较好的作用,对重度患者适当给予唑吡坦等不良反应少的催眠药可显著提高PSQI疗效。
Objective： To observe the influence of PSQI and sex hormone of patients with climacteric syndrome after using Tianmeng-Capsules. Method： 3 Capsules would be taken after dinner and before retiring each time for 12 weeks. PSQI would be used to analyzed before and after treatment. FSH, LH and E2 would be tested by radio immunoassay and then compared by statistics before and after treatment. Result： PSQI after treated, including total score, sleeping time, sleeping quality and score of functional disorder, were better than before（P〈0.05＆P〈0.01 ）. Scores of Kupperman in low-grade and mid-grade were significantly decreased（P〈0.05 ）. There was a little influence to sex hormone but not significant.Conclusion：Tianmeng-Capsule was effective to ameliorate insomnia caused by climacteric syndrome in low-grade and mid-grade patients. Meanwhile,PSQI will be significantly improved in high-grade after using certain doses hypnagogue with less side-effect, such as zolpidem.
出处
《亚太传统医药》
2010年第7期29-31,共3页
Asia-Pacific Traditional Medicine
关键词
更年期综合征
甜梦胶囊
失眠
睡眠质量指数
性激素
Climacteric Syndrome
Tianmeng-Capsule
Insonmia
PSQI （Pittsburgh Sleep Quality Index）
Sex Hormone
