C-erbB-2蛋白在乳腺癌中的表达及其临床意义

Expression of C erbB 2 Protein in Breast Cancer and Its Clinical Significance

为探讨Ｃ－ｅｒｂＢ－２蛋白在乳腺癌中的表达及其临床意义，采用免疫组化ＬＳＡＢ法对１０６例乳腺癌标本进行了Ｃ－ｅｒｂＢ－２蛋白检测。结果：Ｃ－ｅｒｂＢ－２蛋白表达阳性率为６３．２１％（６７／１０６）；生存时间≤５年及＞１０年者，其Ｃ－ｅｒｂＢ－２蛋白表达阳性率分别为８１．６３％和３４．２９％。由此提示：Ｃ－ｅｒｂＢ－２蛋白过度表达与乳腺癌的临床分期晚、组织学分级高及腋窝淋巴结转移有关。Ｃ－ｅｒｂＢ－２蛋白的过度表达是判断乳腺癌预后的一个重要因素，可将Ｃ－ｅｒｂＢ－２蛋白检测作为乳腺癌的常规检测指标之一。

In order to understand the expression of C erbB 2 protein in breast cancer and its clinical significance, we examined the expression of C erbB 2 protein in 106 breast carcinomas by using the immunohistochemical techniques LSAB. The results showed that the positive rate of C erbB 2 expression was 63.21% (67/106). The overexpression of C erbB 2 protein related negatively with survival. 81.63% of the cases with overexpression of C erbB 2 protein survived ≤5 years and 34.29% survived>10 years. There were significant associations of C erbB 2 overexpression with advanced clinical stage, high histological grade, and positive axillary node status in breast cancers. All of these findings suggested that overexpression of C erbB 2 protein might be an important prognostic factor and the detection of C erbB 2 protein might be arranged as a regular pathological examination in the cases of breast cancer.