血管内皮生长因子在脑星形细胞瘤中的表达及其临床意义

Expression of Vascular Endothelial Grwoth Factor in Brain Astrocytoma and Its Clincal Evaluation

脑星形细胞瘤往往伴有血管增生，血管增生程度与其预后密切相关。血管内皮生长因子（ｖａｓｃｕｌａｒｅｎ－ｄｏｔｈｅｌｉａｌｇｒｏｗｔｈｆａｃｔｏｒ，ＶＥＧＦ）被认为是促内皮细胞有丝分裂和血管增生的重要血管生长因子之一。为探索ＶＥＧＦ蛋白表达与星形细胞瘤病理分级和临床预后的关系，采用免疫组织化学方法，结合临床随访，对１０７例脑星形细胞瘤瘤组织和２５例正常脑组织中ＶＥＧＦ蛋白表达水平进行定性和定量检测分析。结果显示：①正常脑组织ＶＥＧＦ表达极低，星形细胞瘤瘤组织ＶＥＧＦ表达明显增高（Ｐ＜０．００５）；②脑星形细胞瘤ＶＥＧＦ表达随其病理分级增加而增高（Ｐ＜０．０１）；③星形细胞瘤ＶＥＧＦ表达愈高的病人，其临床６月、１年、２年存活率愈低。因而，ＶＥＧＦ表达与脑星形细胞瘤病理分级和临床预后密切相关。

Angiogensis is often involved in tumor growth. Neovascularization plays an important role in the prognosis of patients with brain astrocytoma. Vascular endothelial growth factor (VEGF) has been known as the potent angiogentic factor and mitogen. To gain a deep insight into the possible relation between expression of VEGF and pathological characterization/prognosis in brain astrocytoma, the authors investigated 107 cases of brain astrocytoma and 25 cases of normal brain, tissue via a combination of immunohistochemical staining of paraffin embedded tissue and follow up survey. The results showed that the positive staining rate and PU (postive unit) were obviously higher in astrocytoma than that in normal brain (86.92% vs 16.00%, P<0.05) , that the value of the positive staining rate and PU in astrocytoma corresponded closely with its pathological grade and stage ( P<0.01) , and that the survival rates (6, 12,24 months) for the patients suffering from astrocytoma gradually decreased when the VEGF positive rate increased.These suggest that the expression of VEGF may have close relationship with brain astrocytoma and the measurement of the VEGF expression may provide another potential standard for judgement about pathological grade/stage and clinical prognosis in brain astrocytoma.