青蒿琥酯对豚鼠哮喘模型抑制作用的研究

Anti asthmatic effect inhibition of artesunate on the asthmatic model of guinea pig

目的：研究青蒿琥酯对豚鼠哮喘模型的平喘作用。方法：豚鼠组胺与乙酰胆碱引喘法，治疗药物采用雾化吸入和灌胃２种给药途径。结果：雾化或灌胃给药，青蒿琥酯均对药源性哮喘呈现剂量依赖性明显的抑制作用，其半数有效剂量（ＥＤ５０）分别为（９９．９５±７．６９）ｍｇ·Ｌ－１（ｎ＝４）和（１５．６４±１．２５）ｍｇ·ｋｇ－１·ｄ－１（ｎ＝４），其抑制作用与给药的剂量之间呈良好线性关系。结论：青蒿琥酯对豚鼠哮喘模型有一定的平喘作用。

OBJECTIVE:To study the anti asthmatic effects of artesunate on the durg induced asthmat.METHOD:Drug induced asthmatic model of guinea pig.RESULTS:Using nubilous inhalation or intragastric administration,artesunate significantly inhibited the guinea pig model asthma in a dose dependent manner.It's ED 50 were (99.95±7.69)mg·L -1 ( n =4) and (15.64±1.25)mg·kg -1 ·d -1 ( n =4) respectively.CONCLUSION:artesunate showed anti athmatic effect in guinea pig asthmatic model.