左旋硝基精氨酸甲酯对脑缺血再灌注后海马区细胞凋亡的影响

Effect of L NAME on apoptosis in the gerbil hippocampus after recirculation following ischemia

目的：探讨一氧化氮合酶抑制剂左旋硝基精氨酸甲酯（ＬＮＡＭＥ）与脑缺血再灌注后海马区细胞凋亡的关系。方法：钳夹沙土鼠的双侧颈总动脉制造脑缺血模型，应用Ｔｕｎｅｌ法染色，以便观察细胞凋亡的变化及分布。结果：ＬＮＡＭＥ能明显抑制ＣＡ１区细胞凋亡的发生。

OBJECTIVE:To observe effect of L NAME on apoptosis in the gerbil hippocampus after recirculation following ischemia.METHOD:Bilateral occlusion of common carotid arteries and TUNEL stain methods in gerbitil hippocampal tissue slice were used.RESULTS:L NAME inhibited apoptosis in the CA 1 subfield.CONCLUSION:Endogenous NO mediated apoptosis is inhibited by the L NAME.