TIMI危险积分与N-末端脑利钠肽前体在非ST段抬高急性冠脉综合征患者中的相关性研究

THE RELATIONSHIP OF TIMI RISK SCORE AND N-TERMINAL PROBRAIN NATRIURETIC PEPTIDE IN PATIENTS WITH NON-ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME

目的探讨非ST段抬高急性冠脉综合征(NSTEACS)患者TIMI危险积分与血浆N-末端脑利钠肽前体(NT-ProBNP)水平的相关性。方法入选70例非ST段抬高急性冠脉综合征患者,对其进行TIMI危险评分积分,并进行危险分层,采用荧光免疫法测定血浆NT-ProBNP水平,分析其与TIMI危险积分不同层次之间的关系。结果血浆NT-ProBNP水平与TIMI危险积分呈正相关(r=0.71,P<0.05);随着TIMI危险积分评分值增加,血浆NT-ProBNP水平亦逐渐升高,随访期主要心血管事件发生率也增多(P<0.05)。结论 TIMI危险积分与NT-ProBNP水平呈正相关,并与NSTEACS预后有关,能对患者进行危险分层。

Objective To investigat the correlation of TIMI risk score and plasma N-terminal probrain natriuretic peptide（NT-ProBNP）in patients with non-ST segment elevation acute coronary syndrome.Methods The levels of plasma N-terminal probrain natriuretic peptide were measured by fluoroimmunoassay in 70 patients with non.ST segment elevation acute coronary syndrome,and TIMI risk score were calculated.Results The TIMI risk score was positively correlated with the plasma NT-ProBNP level（r=0.71,P0.05）.Conclusion The TIMI risk score is positively correlated with the plasma NT-ProBNP level.The higher TIMI risk score and NT-ProBNP level are,the worse the prognosis becomes,which can be used to predict the prognosis.