酒精性脂肪肝及健康人生化指标的比较

COMPARISON OF SERUM INDICATORS OF PEOPLE WITH ALCOHOLIC FATTY LIVER AND NONALCOHOLIC FATTY LIVER

目的探讨非酒精性脂肪肝及酒精性脂肪肝者的临床生化指标的特点。方法对84例非酒精性脂肪肝、68例酒精性脂肪肝、80例健康对照者及22例嗜酒无脂肪肝的血清酶、血脂、血糖等指标进行检测分析。结果脂肪肝组(包括NAFLD和AFLD)与健康对照组比较ALT、AST、GGT、GLU、CH、TG均有明显升高;AFLD组ALT、AST、GGT、CH、TG血清浓度明显高于嗜酒无脂肪肝组;AFLD组AST、GGT血清浓度明显高于NAFLD组;多因素Logistic分析显示TG、BMI、WHR是NAFLD的危险因素。结论脂肪肝患者血清酶、血脂、血糖升高,酒精性脂肪肝患者肝功能损伤较非酒精性脂肪肝患者严重,肥胖、高血脂为非酒精性脂肪肝发病的危险因素。

Objective To investigate the clinical biochemical indicators of people with alcoholic fatty liver disease （AFLD）and non-alcoholic fatty liver（NAFLD）.Methods 84 NAFLD patients,68 AFLD patients,80 controls who did not abuse alcohol and 22 controls who abused alcohol received serum biochemicals determination and analysis.Results The serum concentrations of ALT,AST,GGT,GLU,CH,TG in FLD group（NAFLD and AFLD included） were higher than those in controls who did not abuse alcohol,the differences were statistically significant（P 0.05）.The serum concentrations of ALT,AST,GGT,CH,TG in AFLD group were higher than those in excessive drinking controls without liver disease （P 0.05）.The serum concentrations of AST,GGT in AFLD group were higher than those in NAFLD（P0.05）.High level of TG,increasing BMI and increasing WHR were risk factors of NAFLD according to the Logistic regression analysis.Conclusion Serum levels of enzymes,blood lipids,GLU of patients with fatty liver may increase.Hepatic impairment is more serious in people with AFLD than that in people with NAFLD.Obesity and hyperlipidemia are the main risk factors of NAFLD.