基于事件相关电位的电针干预海洛因渴求的脑机制研究

An Event Related Potential Research:Electroacupuncture on Male Patients with Heroin Dependence

目的:采用事件相关电位dot-probe范式探讨电针干预海洛因戒断者注意偏向的脑机制。方法:以dot-probe为事件相关电位的刺激模式,观察海洛因戒断者完成认知实验任务实施电针前后数据,选取Fz、Cz、Pz作为主要观察电极点,对事件相关电位中P200、N300两个认知成分进行分析比较。结果:电针前,实验组对吸毒线索及负性情绪线索的注意偏向均高于对照组(P<0.05);电针后,实验组对吸毒线索和负性情绪线索的注意偏向均低于电针前(P<0.05)。结论:电针能干预海洛因戒断者对于吸毒线索的注意偏向,抑制负性情绪线索的注意水平,提高正性情绪线索的注意偏向水平。

Objective： To study the effects of electroacupuncture on attentional bias of male patients with heroin dependence （MPHD） adopting dot-probe model of event related potential （ERP）. Methods： Three main ERP electrodes, Fz, Cz, Pz were recorded in MPHD group and normal group. Before and after electroacupuncture, P200 and N300 were analyzed and compared. Results： Before electroacupuncture, the attentional biases of drug-related and negative emotional clues were higher in MPHD group than those in control group （P 〈 0.05） . After electroacupuncture, the attentional biases of drug-related and negative emotional clues were lower in MPHD group （ P 〈 0.05 ）. Conclusion： Electroacupuncture can affect the attentional bias of drug-related clues in MPHD, inhibit the attentional bias of negative emotional clues and increase attentional bias of positive emotional clues.