盐酸戊乙奎醚与阿托品合用救治有机磷农药中毒70例临床观察

Clinical Analysis of Effects of Changxiaotuoning on Cases of Organophosphorus Poisoning

目的:通过临床对照探讨长托宁(盐酸戊乙奎醚)与阿托品合用在救治有机磷农药中毒中的作用和优缺点。方法:随机将70例急性有机磷药中毒患者分为治疗组和对照组。治疗组用氯磷定和阿托品联合盐酸戊乙奎醚救治,对照组用氯磷定和阿托品救治。结果:治疗组39例,无死亡;对照组31例,死亡1例。阿托品与盐酸戊乙奎醚合用治疗效果优于阿托品,可在最短时间内达到阿托品化,其药物作用时间长,毒副作用小,用药次数、用药总量均明显减小(P<0.05)。结论:治疗有机磷农药中毒盐酸戊乙奎醚与阿托品合用优于单独使用阿托品。

Objective：To evaluate advantage and treatment effects of Changxiaotuoning and Atropine comparing with Atropine on organophosphorus poisoning patients.Methods：70 patients of organophosphorus poisoning（opp）were randomly divided into therapy group（n=39）and control group（n=31）,The therapy group were treated by Pyraloximi Methochloridum,Changxiaotuoning and Atropine.The control group were treated by Pyraloximi Methochloridum and Atropine.Results：There was one case died in the therapy group,and no case died in the control group.In the same condition,Changxiaotuoning and Atropine has slighter side effect,less times of treatment and less total dose than Atropine.It can decrease mortality and its toxicity is low.Conclusion：Changxiaotuoning and Atropine has an advantage over atropine in treatment of organophosphorus poisoning patients.