EZH2在大肠癌中的表达及其临床意义

Expression and Clinic Significance of EZH2 Protein in Primary Human Colorectal Carcinoma

目的:探讨果蝇zeste基因增强子同源物2(EZH2)蛋白在大肠癌中的表达状况及其临床意义。方法:应用免疫组化S-P法检测大肠癌60例、正常大肠组织10例中EZH2蛋白的表达。结果:EZH2蛋白主要表达于细胞核,大肠癌、正常大肠组织的EZH2蛋白阳性表达率分别是71.7%(44/50)、0.0%(0/10),EZH2蛋白在大肠癌组织中的表达明显高于在正常大肠组织中的表达(χ2=15.68,P<0.01)。且EZH2蛋白在大肠癌中的表达与性别、年龄、分化程度、临床分期、大体分型、癌肿大小有关。结论:EZH2异常表达与原大肠癌的发展密切相关,在大肠癌的发展过程中起重要的作用。

Objective：This study is to explore the expression and clinic significance of EZH2（enhancer of zeste homolog 2）protein in human colorectal carcinoma.Methods：The expressions of EZH2 protein in 60 colorectal carcinoma tissues,10 normal tissues were assessed by immunohistochemical method.Results：The expressions of EZH2 protein was located at nucleus.The rate of expressions of EZH2 protein in cancer tissues,normal tissues were 71.7%（44/50）、0.0%（0/10）respectively.The expressions of EZH2 protein in cancer tissues was higher than that in normal tissues（χ^2=15.68,P 0.01）.The expressions of EZH2 protein in cancer tissues was correlated with the tumor size、sex、differentiation、clinical stage、typing、tumor size.Conclusion：The abnormal expression of EZH2 are closely associated with the development of human colorectal carcinoma,which may play an important role in the development of primary human colorectal carcinoma.