羟丁酸钠对罗哌卡因中毒小鼠惊厥和死亡率的影响

The effect of sodium oxybate on the convulsion and mortality rate in ropivacaine-poisoned mice

目的探讨不同剂量羟丁酸钠对罗哌卡因中毒小鼠惊厥和死亡率的影响。方法小鼠分4组,每组10只,分别预先腹腔注射3种剂量的羟丁酸钠或等容积的生理盐水,5 min后腹腔注射致惊厥量罗哌卡因,观察小鼠惊厥潜伏期、持续期、惊厥发生率和死亡率。结果与生理盐水组相比,羟丁酸钠组小鼠惊厥发生率降低,惊厥的潜伏期延长,持续期缩短,死亡率降低。结论羟丁酸钠能降低罗哌卡因毒性并可呈剂量依赖性地拮抗小鼠罗哌卡因中毒引起的惊厥。

Objective To investigate the effect of different doses of sodium oxybate on the convulsions and mortality rate of mice with ropivacaine poisoning.Methods 40 mice were randomized into 4 groups（n=10 each） and received intraperitoneal injections of sodium oxybate of three different doses or the same volume of normal saline,respectively.5 minutes later,all the mice received an intraperitoneal injection of ropivacaine in a toxic dose and the convulsion latency,duration,seizure incidence and mortality of the 40 mice were observed and recorded.Results Compared with the normal saline group,the sodium oxybate groups had a lower convulsion rate,longer latency of the convulsion,shorter duration and reduced mortality.Conclusion Sodium oxybate could decrease ropivacaine toxicity with a dose-dependent response.