Ⅰ型糖尿病患者合并甲状腺免疫紊乱情况观察

Investigation of thyroid autoimmunity in typeⅠdiabetics

目的探讨Ⅰ型糖尿病(T1DM)患者合并甲状腺免疫紊乱的发生情况。方法对43例T1DM患者、60例2型糖尿病(T2DM)患者、40例健康对照者(NC)进行甲状腺过氧化物酶抗体(TPO-Ab)、甲状腺球蛋白抗体(TG-Ab)、甲状腺激素受体抗体(TR-Ab)检测。测定数据经统计学处理,阳性率的比较采用x2检验。结果 T1DM患者TPO-Ab的阳性率为37.2%,TG-Ab的阳性率为30.2%,TR-Ab的阳性率为28.9%,各种甲状腺抗体的检出率明显高于T2DM患者及NC,差异有统计学意义(P<0.01)。结论 T1DM患者易合并甲状腺自身免疫紊乱。

Objective To investigate the prevalence of thyroid autoimmunity in type Ⅰ diabetics（T1DM）.Methods The frequencies of thyroperoxidase antibodies（TPO-Ab）,thyroglobulin antibodies（TG-Ab）and TSH receptor antibodies（TR-Ab）were determinded in 143 subjects,including 43 T1DM,60 type 2 diabetics（T2DM）and 40 controls.Measured data were statistically analyzed,and occurrence rate was compared with x2 test.Results The occurrence rate of TPO-Ab,TG-Ab and TR-Ab in T1DM is 37.2%,28.9%,respectively.The occurrence rates of thyroid autoantibodies in T1DM were more frequent than those in T2DM and controls（P〈0.01）.Conclusion T1DM patients have the higher risks of thyroid autoimmunity.