炎症因子水平与儿童代谢综合征关系的临床意义

Serum concentration of inflammatory factor and metabolism syndrome in children

目的:探讨代谢综合征(MS)患儿血清炎症因子水平变化及意义。方法:60例肥胖儿童根据糖脂代谢紊乱程度分为单纯性肥胖组、代谢综合征组各30例,30例健康者为正常对照组,检测炎症因子-高敏C反应蛋白、白细胞介素6、肿瘤坏死因子α。对上述资料进行统计分析。结果:单纯性肥胖组和代谢综合征组炎症因子水平明显高于正常对照组(P<0.05),且炎症因子水平在单纯肥胖、MS中呈逐渐升高,组间比较差异有统计学意义(P<0.05)。结论:炎症因子在MS和单纯性肥胖患儿中表现出不同程度的升高,血清炎症因子水平可作为判断病情及进展的有效指标。

Objective：To elevate the significance of detecting serum concentration of inflammatory factor in metabolism syndrome（MS） of children. Methods：Sixty children of adiposity were allocated to group of simple obesity（n=30） and metabolism syndrome（n=30） in terms of degree of glycolipid metabolic disturbance,and another 30 healthy subjects were recruited as controls. The inflammatory factors,including high-sensitivity C-reactive protein,interleukin-6,tumor necrosis factor-alpha,were tested in all subjects and the data were statistically analyzed. Results：The inflammatory factors were found significantly higher in the groups of simple obesity and MS as compared with the controls and tended to increase with the degree of glycolipid metabolic disturbance（P0.05）. Conclusion：The fact that inflammatory factors increase to a certain extent in children with simple obesity or MS suggests that detection of the serum concentration of those factors may be valuable in estimating the prognosis of this disorder.