摘要
目的探讨血管紧张素转换酶（ＡＣＥ）基因插入（Ｉ）／缺失（Ｄ）多态性与阳性卒中家族史（ＦＨＳ）性脑卒中的相关性。方法采用聚合酶链反应技术（ＰＣＲ）技术检测４７例阳性ＦＨＳ和１４５例阴性ＦＨＳ脑卒中患者的ＡＣＥ基因插入和缺失多态性。结果阳性ＦＨＳ组的Ｄ等位基因频率（０．７２）明显高于阴性ＦＨＳ组（０．５２），Ｐ＜０．０５。ＤＤ基因型也明显高于阴性ＦＨＳ组（５１．５％ｖｓ２３．５％，ｘ２＝１２．８４，Ｐ＜０．００１）。结论认为ＡＣＥ基因缺失多态性在阳性ＦＨＳ性脑卒中的形成中可能起重要作用。
Objective To study the relationship between insertion (I)/deletion(D) polymorphisms of angiotension converting enzyme (ACE) gene and stroke with positive family history of stroke(FHS).Methods ACE gene polymorphisms of 47 stroke subjects with positive FHS and 145 subjects with negative FHS were identified by PCR.Results D allele frequency (0.72) in positive FHS group was significantly higher than that in negative FHS group (0.46), P <0.05.ACE DD genotype in positive FHS group was also more common than that in negative FHS group (51.1% vs 23.5%), P <0.001.Conclusion Deletion polymorphism of ACE gene might play an important role in the development of stroke with positive FHS.
