盐酸多奈哌齐联合高压氧对伴有认知功能障碍的无症状性脑梗死的效果研究

The Study of a Combined Therapy of Aricept and High Pressure Ressure Oxygen on the Cognition of Silent Brain Infarction

目的探讨盐酸多奈哌齐联合高压氧对伴有认知功能障碍的无症状性脑梗死(silent brain infarction SBI)的研究。方法选择78例SBI患者随机分为两组,每组39例,治疗组采用盐酸多奈哌齐联合高压氧治疗,对照组采用口服安慰剂及高压氧治疗。治疗前及6周采用简易智能精神状态检查表(MMSE)及事件相关电位(ERP)评价其认知功能。结果与治疗前比较,两组MMSE评分均有显著改善(P<0.01),两组P300中N2,P3潜伏期均显著缩短,P3波幅显著升高,两组比较,治疗组MMSE评分要优于对照组,P300中N2,P3潜伏期要短于对照组,P3波幅要高于对照组(P<0.01)。结论盐酸多奈哌齐联合高压氧能明显改善SBI患者的认知功能,且其效果要优于单用高压氧治疗。

Objective To explore the effect of the combined therapy of aricept and high pressure oxygen on the cognition of silent brain infarction.Methods 78 cases of SBI were randomly divided into two groups,each group has 39 cases.the study group was cured with aricept and high pressure oxygen.while the control group was cured with placebo and high pressure oxygen.the MMSE and ERP was used to measure the cognition of two group before and at the end of 6 weeks.Results The score of MMSE of two groups at the end of 6 weeks was significantly higher than that of before in the study of P300（P0.01）.The latency period of N2,P2 was shorter than those of before.the amplitude of wave of P300 was higher than that of before compared with the control group（P0.01）.The score of MMSE in the control group was higher,the latency period of N2,P2 was shorter.the amplitude of wave of P300 was higher（P0.01）.Conclusion The combined therapy of aricept and high pressure oxygen can improve the cognition ability of SBI.The effect of combined therapy was better than that of high pressure oxygen single.