氯吡格雷联合阿司匹林治疗糖尿病并发急性脑梗死的临床研究

The Clinical Study On Clopidogre and Aspirin in The Treatment of Patients with Diabetics Complicated Acute Cerebral Infarction

目的探讨氯吡格雷联合肠溶阿司匹林治疗糖尿病并发急性非心源性脑梗死的早期疗效和安全性。方法选择90例糖尿病并发首次非心源性急性脑梗死的患者,随机分为治疗组(45例)和对照组(45例)。治疗组给予氯吡格雷联合肠溶阿司匹林治疗,对照组给予肠溶阿司匹林治疗,分别在治疗前后进行临床疗效评定、神经功能缺损评分(NDS)及发生出血不良反应统计。结果在糖尿病并发急性非心源性脑梗死的早期治疗中,两组临床疗效比较和神经功能缺损评分比较有统计学意义(P<0.05);两组均无发生脑出血,两组不良反应比较差异无统计学意义(P>0.05)。结论氯吡格雷联合肠溶阿司匹林在糖尿病并发急性非心源性脑梗死的早期治疗中疗效显著,优于单用肠溶阿司匹林,且不良反应轻,出血发生率低,值得临床推广应用。

Objective To study the early efficacy and safety of clopidogrel combined with aspirin in treating patients with diabetics complicated acute non-cardiac cerebral infarction.Methods 90 patients with diabetics complicated acute non-cardiac cerebral infarction were divided into treatment group（45 cases）and control group（45 cases）at random.The therapeutic group is using clopidogrel and aspirin,and the control group is using aspirin only.Evaluation of clinical efficacy,neurological deficit score（NDS）and statistics of bleeding of adverse reaction were respectively undergone before and after treatment.Results Comparing the two groups in the early treatment of patients with diabetics complicated acute non-cardiac cerebral infarction,there was statistical significance in clinical efficacy and NDS no cerebral bleeding occurred in the two groups（P0.01）.There was no statistical significance of side-effect in comparing them（P0.05）.Conclusion Clopidogrel combined with aspirin in the early treatment of patients with diabetics complicated acute non-cardiac cerebral infarction has significant curative effect,and is superior to single aspirin treatment.Moreover,little adverse reaction and low occurrence of bleeding can be found in using clopidogrel combined with aspirin,thus is worthily recommended in clinical application.