摘要
目的探讨度洛西汀对抑郁症的疗效和安全性。方法 70例抑郁发作患者随机分为度洛西汀组和氟西汀组,每组35例,分别给予度洛西汀和氟西汀治疗,疗程6周。用汉密尔顿抑郁量表(HAMD)评定疗效,用不良反应量表(TESS)评定不良反应。结果治疗1~2周,度洛西汀组HAMD评分较氟西汀组显著下降(P<0.05),治疗4~6周,两组相仿(P>0.05)。两组间不良反应差异无显著性(P>0.05)。结论度洛西汀是一种起效较快,且安全、有效的新型抗抑郁药。
Objective To study the efficacy and safety of duloxetine in the treatment of major depression.Methods This was a randomized 6 weeks study,70 outpatients and inpatients diagnosed as depression were randomly assigned into duloxetine group with duloxetine and fluoxetine group with fluoxetine.The efficacy was assessed by Hamilton depression rating scale(HAMD) and the safety was assessed by treatment emergent symptom scale(TESS).Results The mean values of HAMD total scores in the study group was significantly lower than that in the control group at the end of the first two weeks(all P0.05),but there was no significant difference between the two groups at the end of week4,6(P0.05).Conclusion Duloxetine is a safe,effective and rapidly responsive antidepressant.
出处
《实用心脑肺血管病杂志》
2010年第7期920-921,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease