特比萘芬对小鼠胚胎的致畸作用

MALFORMED EFFECT OF TERBINAFINE ON THE MOUSE EMBRYOS

目的研究特比萘芬对小鼠胚胎的致畸作用。方法将特比萘芬用２２５ｍｇ／ｋｇ、４５０ｍｇ／ｋｇ、９００ｍｇ／ｋｇ３个剂量，于小鼠妊娠第６～１５ｄ，每天经口给药１次。结果３个剂量组孕鼠体重增长、着床数、活胎数、吸收胎数、死胎数无明显改变。９００ｍｇ／ｋｇ、４５０ｍｇ／ｋｇ剂量组胎鼠体重、身长改变明显。２２５ｍｇ／ｋｇ剂量组胎鼠体重、身长无明显改变。３个剂量组胎鼠骨骼、外观和内脏均无异常发现。

Objective\ Investigating the malformed effect of terbinafine on the mouse embryos. Methods\ Terbinafine was divided into 225mg/kg, 450mg/kg and 900mg/kg groups. The mice were orally administered terbinafine from the 6th to 15th day after pregnancy once everyday. Results\ After the mice were given different doses of terbinafine, their weight, imbeded number, the number of living embryo, the number of absorbed embryo and the number of dead embryo did not change obviously. As the mice were given 900mg/kg and 450mg/kg of terbinafine, the weight and the body length of the embryo changed apparently. For this reason 900mg/kg and 450mg/kg of terbinafine have a slight inhibition on the mouse embryos growth. As the mice were given 225mg/kg of terbinafine, the weight and the body length of the embryo did not changed apparently. After the pregnant mice were given different doses of terbinafine, the abnormality in statistics was not found in the skeleton of the mouse embryos, the exterior and the internal organs.Conclusions\ Terbinafine has no malformed effect on the mouse embryos.