均匀设计法优选热痹巴布剂制备工艺

Optimization of preparation technology for pyretic arthralgia cataplasma by uniform design

目的:优选热痹巴布剂的制备工艺。方法:采用均匀设计实验,以聚丙烯酸钠(NP-700)、酒石酸、聚乙烯吡咯烷酮K90(PVP)、甘羟铝、甘油、水、药粉为考察因素,以初粘力、透布程度、流膏量、胶强度为指标,研究热痹巴布剂的制备工艺。结果:通过对数据分析,优选出最佳的配方比为NP-700:酒石酸:PVP:甘羟铝:甘油:水:药粉=4.1:0.2:1.0:0.1:25:35:2.0,根据处方配比制备巴布剂膏体,涂布于无纺布上,室温下放置1周,加盖衬,包装即得。结论:本巴布剂成型性良好,制备工艺可行。

Objective： To optimize a preparation technology for pyretic arthralgia cataplasma. Methods： The preparation technology were studied by a uniform design experiment in which NP-700, tartaric acid, PVP, dihydroxyaluminum aminoacetate, glycerol, water and medicinal powder were factors and viscosity, infiltration, gel mobility and gel strength were indices. Results： The best ratio of this cataplasma matrix was NP-700：tartaric acid：PVP：dihydroxyaluminum aminoacetate： glycerol：water：powder = 4.0：0.2：1.0：0.1：25.0：35.0：2.0. According to optimized formula, to prepare the poultice, then to spread the poultice uniformly onto non-woven fabrics, cover CPP membrane and pack after 1 week at room temperature. Conclusion： Pyretic arthralgia cataplasma was well moldable and its process technology was feasible.