柴胡汤治疗甲型H_1N_1流感轻症病例的回顾性分析

Retrospective Analysis on Therapy to Influenza A H_1N_1 Virus Mild Cases with Bupleuri Decoction

目的：探讨甲型H1N1流感轻症病例临床特征及柴胡汤的疗效。方法：回顾性分析甲型H1N1流感轻症80例临床特征、实验室检查以及治疗效果。中西医结合组40例,柴胡汤加味,1剂/天,2次/天,疗程5天。同时口服奥司他韦,75mg,2次/天,疗程5天。抗病毒组40例,口服奥司他韦,75mg,2次/天,疗程5天。应用RT-PCR进行咽拭子甲型H1N1流感病毒核酸检测。结果：两组病例临床症状以发热、咳嗽和咽痛为主,病例确诊平均时间（43±8.76）h,两组病例平均住院时间、临床症状消失时间、咽拭子病毒核酸检测转阴时间无显著性差异（t=0.75~1.17,t〉0.05）。结论：甲型H1N1流感轻症病例预后良好,柴胡汤加味治疗轻症可行。

Objective：To explore the clinical feature of influenza A H1N1 virus mild cases and therapeutic effects of Bupleuri Decoction.Method：Retrospective analysis the clinical feature,laboratory examination and therapeutic effects of 80 mild cases with influenza A H1N1 virus.40 cases in integrated traditional and western medicine group,were given Bupleuri Decoction and other herbs,one dosage a day,two times a day for five days.Meanwhile,received Oseltamivir,75mg,two times a day for five days.40 cases in anti-virus group were given Oseltamivir,75mg,two times a day for five days.All cases received pharynx swAbs viral nucleic acid detected by RT-PCR.Results：The major clinical symptoms were fever,cough and pharyngodynia in the two groups.The mean final diagnosis time（43±8.76）h.There was no significant difference between the two groups in the mean hospitalized time,mean clinical symptom extinct time and mean pharynx swAbs viral nucleic acid negative time（t=0.75~1.17,P〈0.05）.Conclosion： Influenza A H1N1 virus mild cases can be treated and its prognosis is good.It is available for Bupleuri Decoction to treat mile caeses.