小剂量米非司酮治疗围绝经期功能失调性子宫出血

Efficacy of lower dose mifepristone in treating dysfunctional uterine bleeding in perimenopausal period

目的:探讨口服小剂量米非司酮治疗围绝经期功能失调性子宫出血的临床疗效。方法:82例围绝经期功能失调性子宫出血患者给予6.25mg米非司酮片口服,连续服药3个月。于治疗前及治疗1、2、3、6个月分别测定血清激素水平,观察月经情况,同时监测子宫内膜厚度。结果:米非司酮治疗患者服药期间均闭经,用药后患者血清雌二醇(E2)、孕酮(P)和泌乳素(PRL)的平均水平较用药前均有不同程度的下降(P<0.05);卵泡刺激素(FSH)、黄体生成素(LH)变化不明显(P>0.05),贫血得到纠正,无子宫内膜增厚。结论:6.25mg小剂量米非司酮可有效治疗围绝经期功能失调性子宫出血,具有一定的临床应用价值。

Objective： To investigate the efficacy of mifepristone in treating dysfunctional uterine bleeding in perimenopausal period. Methods： 82 patients with dysfunctional uterine bleeding in perimenopausal period were treated with 6.25 mg mifepristone daily for 3 months. Effects of mifepristone on inducing amenorrhea, the changes of endocrine and the pathology of endometrium were observed before treatment and after 1, 2, 3 and 6 months treatment. Results： All patients were amenorrhea during treatment with mifepristone. Serum estradiol （E2）, progestone （P） and prolactin （PRL） level showed significantly decreased after treatment （P0.05）. No significant changes of serum follicle-stimulating hormone （FSH） and luteotrophic hormone （LH） levels were found after 6 months treatment. The endometrium were atrophied and anemia was improved in patients after treatment. Conclusion： Treatment of lower dose mifepristone （6.25 mg, daily） is a safe and effective method for treating dysfunctional uterine bleeding in preimenopausal period.