江阴市人民医院感染铜绿假单胞菌的耐药性分析

Analysis on Antibiotic Resistance of Pseudomonas Aeruginosa Infected in People's Hospital of Jiangyin City

目的了解江阴市人民医院感染铜绿假单胞菌的耐药性情况,为临床诊治、合理用药提供参考。方法收集2008年1月—12月该院各科临床标本并分离、培养铜绿假单胞菌,采用回顾性分析方法统计594株铜绿假单胞菌的标本来源、科室分布以及耐药状况。结果铜绿假单胞菌从痰标本中分离菌株最多,医院感染铜绿假单胞菌主要分布在ICU、脑外科、胸心外科、呼吸科,该菌对氨曲南、环丙沙星、左旋氧氟沙星、庆大霉素、妥布霉素、头孢他啶、亚胺培南、美罗培南、头孢哌酮/舒巴坦的耐药率依次为76.94%、70.37%、68.86%、67.50%、66.84%、66.67%、55.22%、37.54%、11.11%。结论需要加强该院感染铜绿假单胞菌的耐药性监测并合理使用抗菌药物,以减少耐药菌株的产生。

[Objective]To study the antibiotic resistance of pseudomonas aeruginosa infected in People＇s Hospital of Jiangyin City,and provide reference for the clinical diagnosis and reasonable medication.[Methods]Clinical specimens from each department were collected for pseudomonas aeruginosa isolation and culture during January-December 2008.Retrospective analysis was adopted to identify the specimen sources,department distribution and resistant situation of 594 strains of pseudomonas aeruginosa.[Results]Most strains were isolated from sputum specimens.The infection of pseudomonas aeruginosa mainly occurred in ICU,thoracic surgery department,cardiothoracic surgical department and respiratory department.The resistance rate to aztreonam,ciprofloxacin,levofloxacin,gentamicin,tobramycin,ceftazidime,imipenem,meropenem,cefoperazone / sulbactam was 76.94%,70.37%,68.86%,67.50%,66.84%,66.67%,55.22%,37.54%,and 11.11%,respectively.[Conclusion]It is necessary to strengthen the resistance monitoring of pseudomonas aeruginosa and rational use of antibiotics to reduce the production of resistant strains.