胰岛素联合用药治疗2型糖尿病的临床研究

Clinical Research about Intensification Therapy of Trypsin with Drug Combination on Treatment of Type 2 Diabetes

目的探讨两种胰岛素联合用药强化治疗方案治疗2型糖尿病的临床效果。方法将2008年1月至2009年5月间在佛山市南海区第二人民医院住院治疗的2型糖尿病患者72例随机分为A组、B组和C组,A组应用诺和锐30联用拜唐平,B组应用诺和灵30R和二甲双胍,C组单纯应用诺和灵30R,评估3组治疗效果。结果 A组、B组治疗后FPG、2hPG、HbA1C明显低于C组(P<0.05)。A组与B组治疗后FPG、2hPG、HbA1c分别比较差异无统计学意义(P>0.05)。3组治疗后BMI指标相互比较差异无统计学意义(P>0.05)。A组、B组总有效率明显高于C组,两组分别比较差异具有统计学意义(P<0.05)。A组总有效率与B组比较差异无统计学意义(P>0.05)。A组、B组胰岛素用量明显少于C组,两组分别比较差异具有统计学意义(P<0.05)。不良事件发生率A组、B组明显低于C组(P<0.05),A组发生率与B组比较差异无统计学意义(P>0.05)。结论两种强化治疗方案均能有效地控制血糖,值得临床广泛应用。

Objective To investigate the effect of intensification therapy of two trypsins with drug combination on treatment of type 2 diabetes.Method The 72 cases with type 2 diabetes in the second people＇s hospital of Nanhai district from January in 2008 to may in 2009 were divided into the A group,B group and C group,the A group received the treatment of novorapid 30 combined with glucobay,the B group received the treatment of novolin 30R and diformin,and the C group received the treatment of novolin 30R.Results The level of FPG,2hPG and HbA 1 C after treatment in the A group and B group was lower than those in C group,and there was significant difference in them respectively（P〈0.05）.There was on significant difference respectively on the level of FPG,2hPG and HbA 1 C after treatment in the A group and B group（P〉0.05）.There was no significant difference in them respectively about level of BMI after treatment（P〉0.05）.The total effective rate in A group and B group was higher than that in C group and there was significant difference in them respectively（P〈0.05）.The total effective rate in B group was same to that in A group,and there was no significant difference in them respectively（P〉0.05）.The usage amount of trypsin in A group and B group was lower than that in C group and there was significant difference in them respectively（P〈0.05）.The bad incident in A group and B group was lower than that in C group and there was significant difference in them respectively（P〈0.05）.Conclusion The two kinds of intensification therapy can control the level of blood sugar well,so they are worth being used.