腺病毒载体与肿瘤基因治疗

Adenovirus Vector and Cancer Gene Therapy

基因导入系统是恶性肿瘤基因治疗中急需解决的问题．由于腺病毒作为载体介导外源效应基因在肿瘤细胞中的高效表达，使其应用日趋增多．用于肿瘤基因治疗的腺病毒可分为复制缺陷型和复制型．常用的效应基因包括：抑癌基因，前药转换酶基因。

It's necessaty to construct a gene transfer system in the gene therapy for the malignant tumor.Adenovirus as a vector are used more and more because it can mediate the expression of the foreign etfector gene at high level in the tumor cells.The adenovirus which are used in the cancer gene therapy can be classified into replicating deficient form and replicating form.The etfector gene such as tumor suppressor gene,pro drug gene,ribozyme gere,cytohine gene and et,are often used.