糖克宁对链脲佐菌素所致糖尿病大鼠降糖机理的研究

Mechanism of Tangkening in Reducing Blood Sugar in Rats with Diabetes Caused by Streptozotocin

目的：观察中药糖克宁对糖尿病大鼠降糖作用和机理。方法：用ＳＴＺ成功地制造了大鼠糖尿病模型，用中药糖克宁连续治疗８ｄ。结果：ＳＴＺ糖尿病大鼠的高血糖反应明显减轻，与模型组比较，差异有高度显著性，糖克宁组治疗后胰岛素和Ｃ肽水平有增高趋势。组织学研究提示糖克宁组大鼠胰腺组织中的胰岛数目较模型组增多，胰岛内细胞数亦相对增多，淋巴细胞浸润减少，炎症反应减轻。结论：糖克宁对糖尿病大鼠有较好的降糖作用，其作用机理可能是通过抵制或减轻自身免疫反应，减轻ＳＴＺ对胰岛β细胞损伤，或促进已损伤的β细胞的修复，增强胰岛的分泌功能，从而减轻高血糖反应。此外还可能与益气养阴、活血化瘀类中药改善机体内环境，促进组织器官的血液循环。

OBJECTIVE:To observe the mechanism of Tangkening in reducing the blood sugar in rats with diabetes.METHOD:Rat diabetes models were made with STZ and were than treated with the Chinese drug Tangkening for 8 days.RESULT:The diabetic rats' blood sugar was reduced significantly as compared with the model group.The level of insulin and C peptide in the Tangkening Group increased.Histological researches indicated that in the Tangkening Group, the number of islets of Langerhans was greater than that in the model group,the number of cells in the islets of Langerhans increased,and there was a reduction in the infiltration of lymphocytes and inflammatory reaction.CONCLUSION:Tangkening has good effect in reducing blood sugar in rats and its mechanism lies in its funvitions to antagonize or relieve autoimmunity,reduce the damage of β cells caused by STZ,promote the repair of the damaged β cells and improve the secretion of the islets of Langerhans.The mechanism also has something to do with the functions of the drug to improve intemal environment,activate blood circulationr and enhance the sensitivity of insulin receptor in the tissue target cell.