阿昔洛韦治疗贝尔麻痹

Aciclovir in treating Bell's palsy

目的：观察阿昔洛韦治疗贝尔麻痹的疗效。方法：６９例贝尔麻痹病人随机分为阿昔洛韦组３６例，男性１９例，女性１７例，年龄（３４±ｓ１１）ａ，１５～６１ａ，口服阿昔洛韦０．２ｇ，ｑ６ｈ；泼尼松组３３例，男性１６例，女性１７例，年龄（３７±１１）ａ，１１～５７ａ，口服泼尼松（强的松）１０ｍｇ，ｔｉｄ；２组均给予呋喃硫胺注射液２０ｍｇ，ｉｍ，ｑｄ。疗程均为２ｗｋ。结果：阿昔洛韦组治愈率为４７％，总有效率为９７％；泼尼松组为１２％和６４％。经Ｒｉｄｉｔ分析，Ｐ＜０．０５。阿昔洛韦组４例（４／３６）有轻度胃不适。结论：阿昔洛韦为治疗贝尔麻痹的有效药物，且毒副作用少。

AIM: To observe the efficacy of aciclovir in treating Bell's palsy. METHODS: Patients (n=69) with Bell's palsy were randomly divided into 2 groups. Patients(n=36) as treatment group [M 19, F 17; age (34±s 11) a, 15～61 a] were treated with aciclovir 0.2 g, po, q 6 h for 2 wk. The other 33 patients in prednisone group [M 16, F 17; age (37±11) a, 11～57 a] were treated with prednisone 10 mg, po, tid for 2 wk. They were all given fursultiamine 20 mg, im, qd for 2 wk. RESULTS: The total effective rate, cure rate were 97%, 47% and 64%, 12%, respectively (Ridit's analysis: P<0.05). The adverse reactions were mild. CONCLUSION: Aciclovir in treating Bell's palsy is effective and safe.