温石棉的遗传毒性及三种化合物的阻断作用

. GENOTOXICITY OF CHRYSOTILE AND INHIBITORY EFFECTS OF THREE CHEMICALS

为了寻求一种理想的石棉表面改性剂，本研究观察了柠檬酸铝、混合稀土或亚硒酸钠对温石棉诱导人胚肺（ＨＥＬ）细胞染色体改变的影响。结果显示，温石棉可致ＨＥＬ细胞染色体畸变率和姊妹染色单体交换率升高。经三种化合物预处理的温石棉，其所诱导的ＨＥＬ细胞的染色体畸变率和姊妹染色单体交换率均低于未处理温石棉组。提示，用三种化合物预处理温石棉，均可降低温石棉对细胞染色体的损伤作用。

To look for an ideal chemical for surface modification of asbestos, the effects of aluminium citrate, mixed rare earths and sodium selenite on the induction of chromosomal aberrations and sister chromatid exchanges (SCEs) by chrysotile in human embryo lung cells were observed. The results showed that chrysotile caused increases of chromosomal aberrations and SCEs in HEL cells, but the three compounds-pretreated chrysotile induced less chromosomal aberrations and SCEs than the native chrysotile. These results indicated that the pretreatment of chrysotile with three compounds can inhibite the damage effects of chrysotile on the chromosome of HEL cells and may reduce the carcinogenicity of chrysotile.