去乙酰基长春花碱酰胺硫酸盐大鼠生殖毒性研究

REPRODUCTIVE TOXICITY STUDY OF VINDESINE SULFATE IN WISTAR RATS

Ｗｉｓｔａｒ雌、雄大鼠在交配前每周一次ｉｖ给予去乙酰基长春花碱酰胺硫酸盐（ｖｉｎｄｅｓｉｎｅｓｕｌｆａｔｅ，ＶＤＳ），共分别给药３次和９次，各组剂量分别为０．０５ｍｇ／ｋｇ、０．１ｍｇ／ｋｇ、０．２ｍｇ／ｋｇ。１∶１同笼交配２ｗｋ，期间继续按前给药，孕鼠于孕期第６、１２ｄ各给药一次。结果各剂量组雄鼠体重增重明显减少；高剂量组孕鼠死胎率增加，胎仔尾长和体重明显小于对照组；各剂量组胎仔骨骼发育迟缓，未见外观、内脏和骨骼畸形。结果表明ＶＤＳ对Ｗｉｓｔａｒ大鼠具有胚胎毒性，无致畸作用。

The reproductive toxicity of vindesine sulfate (VDS) in Wistar rats was carried out. Before mating trial, VDS was iv given once a week at 0.05, 0.1 and 0.2 mg/kg to male rats (9 doses) and to female rats (3 doses). The administration was same to both rats during the mating trial (1∶1 cohabitation, for up to 2 weeks) and to mated females on day 6 and 12 postcoitus (pc). Mated females were killed on day 20 pc.As compared to the saline control, the body weight gain of males from every dosage group is less.In high dosage of VDS ( 0.2 mg/kg), the percentage of dead fetus is higher and the tail length and body weight of survival fetuses is less. The percentage of delayed skeletogency of every dosage group is higher. No malformation of survival fetuses was observed in every group. The study indicated that VDS is embryotoxic but not teratogenic in Wistar rats and has no obvious effect on reproductive performance of both sexes.