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肿瘤抑制基因第10号染色体缺失的磷酸酶和张力蛋白同源等位基因在神经元回路形成与维持中的作用

Function of Phosphatase and Tensin Homologue Deleted on Chromosome 10 in Formation and Maintenance of Neuronal Circuits in Brain
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摘要 肿瘤抑制基因第10号染色体缺失的磷酸酶和张力蛋白同源等位基因(PTEN)在多种类型细胞中通过抑制磷脂酰肌醇-3激酶(PI3K)信号通路在细胞增殖、移行和凋亡调控中发挥重要作用。大量体内、体外实验表明,PTEN/PI3K信号下调与神经元形态改变存在直接关系,并与许多神经精神疾病的发病机制相关。现就PTEN在大脑发育和神经元回路形成与维持中的作用进行综述。 Phosphatase and tensin homologue deleted on chromosome 10 （PTEN） is a tumor suppressor which can inhibit proliferation and migration and control apoptosis in a number of cell types, mainly through inhibiting the phosphoinositide 3 - kinase（PI3K） signaling pathway. A number of in vitro and in vivo studies has been instrumental in uncovering a direct correlation between deregulated PTEN/PI3K signaling and changes in neuronal morphogenesis, which is likely to have profound bearings upon the pathogenesis of neurological symptoms. This review outlines recent work on the function of PTEN during the formation and maintenance of neuronal circuits in the brain.
作者 赵婧 李德渊 屈艺 母得志
机构地区 四川大学华西第二医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2010年第14期1107-1109,共3页 Journal of Applied Clinical Pediatrics
基金 国家自然科学基金(30825039 30973236)
关键词 第10号染色体缺失的磷酸酶和张力蛋白同源等位基因 神经元回路 磷脂酰肌醇-3激酶信号 phosphatase and tensin homologue deleted on chromosome 10 neuronal circuits phosphoinositide 3 -kinase signaling
分类号 R33 [医药卫生—人体生理学]
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参考文献31

  • 1韩宇,曹青山,常廷民,王光辉,杨承汉.食管癌中抑癌基因PTEN的表达及临床意义[J].新乡医学院学报,2007,24(2):109-110. 被引量：8
  • 2i Stiles BL. Phosphatase and tensin homologue deleted on chromosome 10 : Extending its PTENtacles [ J ]. Int J Biochem Cell Biol, 2009,41 ( 4 ) : 757 -761.
  • 3Planchon SM, Waite KA, Eng C. The nuclear affairs of PTEN [J]. J Cell Sci,2008,121 (3) :249 - 253.
  • 4Thaker NG, Pollack IF. Molecularly targeted therapies for malignant glioma:Rationale for combinatorial strategies [ J ]. Expert Rev Neurother, 2009,9 (12) :1815 - 1836.
  • 5Cai QY, Chen XS, Zhong SC, et al. Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p - Akt in the ischemic cerebral cortex[ J]. Anat Rec,2009,292 (4) :498 -512.
  • 6Groszer M, Erickson R, Scripture - Adams D, et al. PTEN negatively regulates neural stem cell self - renewal by modulating G0 - G1 cell cycle entry[ J]. Proc Nat Acad Sci USA ,2006,103 ( 1 ) : 111 - 116.
  • 7Gregorian C, Nakashima J, Le Belle J, et al. Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis [J]. J Neurosci,2009,29 (6) :1874 - 1886.
  • 8Groszer M, Erickson R, Scripture - Adams DD, et al. PTEN negatively regulates neural stem cell self - renewal by modulating G0- G1 cell cycle entry[ J]. Proc Natl Acad Sci USA ,2006,103 ( 1 ) : 111 - 116.
  • 9Yue Q, Groszer M, Gil JS, et al. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization [ J ]. Developmerit ,2005,132 ( 14 ) :3281 - 3291.
  • 10Grider MH, Park D, Spencer DM, et al. Lipid raft - targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac 1, respectively [ J ]. J Neurosci Res, 2009,87 ( 14 ) : 3033 - 3042.

二级参考文献10

  • 1常栋,李汉臣.食管癌中抑癌基因PTEN研究进展[J].新乡医学院学报,2005,22(3):281-284. 被引量：1
  • 2Steek PA,Pershouse MH,Jasser SA,et al.Identification of a candidate tumor suppressor gene,MMACL,at chromosome 10q23.3 that in mutated in maltiple advanced cancers[J].Nat Genet,1997,15(1):336-342.
  • 3Li DM,Sun H.TEPI,encoded by a candidate tumor suppressor locus,is a novel protein tyrosine phoshatase regulated by transforming growth factorB[J].Cancer Res,1997,57(11):2 124-2 134.
  • 4Li J,Yen c,Liaw D,et al.PTEN,a putative protein tyrosine phosphatase gene mutated in human,breast,and prostate cancer[J].Science,1997,275(9):1 943-1 960.
  • 5Frisk T,Foukakis T,Dwight T,et al.Silencing of the PTEN tumor suppressor gene in anaplastic thyroid cancer[J].Genes Chromosomes Cancer,2003,35(1):74-80.
  • 6Li L,Liu F,Ross A.PTEN regulation of neural development and CNS stem cells[J].Cell Biochem,2003,88(1):24-28.
  • 7Tachibana M,Shibakito M,Ohno S.Expression and prognostic significance of PTEN product protein in patient with esophagel squamous cell carcinoma[J].Cancer,2002,94(7):1 955-1 960.
  • 8Hwang PH,Yi HK,Kim DS,et al.Suppression of tumorigenicity and metastosis in B16F10 cells by PTEN /MMACI/TEPI gene[J].Cancer Lett,2001,172(1):83-91.
  • 9况立革,杨琳,王艳萍,李锦毅,吴东瑛,张素敏,辛彦.PTEN基因编码产物与胃癌发生发展相关性的研究[J].肿瘤防治杂志,2002,9(5):472-475. 被引量：9
  • 10高新平,王建设,朱命炜,赵卫星,王全智.食管癌发生过程中抑癌基因PTEN表达与微量元素含量分析[J].新乡医学院学报,2004,21(1):5-7. 被引量：3

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实用儿科临床杂志
2010年 第14期

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