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对比剂肾病的研究进展 被引量:4

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摘要 目的:综述关于对比剂肾病的发病机制,危险因素及其预防方法的研究进展。方法:查阅国内外相关文献,进行分析、归纳、总结。结果:对比剂肾病的危险因素包括慢性肾功能不全、糖尿病、充血性心力哀竭、高龄(>75岁)、围手术期血流动力学不稳定等,且危险因素具有累加效应;发病机制可能与对比剂致肾脏血流动力学的改变及对肾小管上皮细胞的直接毒性有关;预防方法包括对比剂的合理选择,水化治疗,抗氧化剂N-乙酰半胱氨酸的应用等。结论:对比剂肾病应引起临床医生的高度重视,目前临床上对对比剂肾病主要以预防为主,还需积极寻找新的、更有效的防治措施。
作者 王柳 陆士娟
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2010年第14期1223-1225,共3页 Chinese Journal of Hospital Pharmacy
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