食管静脉曲张破裂出血内镜套扎术后联合生长抑素预防近期再出血的临床研究

Effects of somatostatin in preventing esophageal variceal rebleeding after endoscopic ligation

目的:观察食管静脉曲张破裂出血行食管静脉曲张内镜套扎术(EVL)后联合使用生长抑素对预防近期再出血的有效性。方法:144例静脉曲张破裂引起上消化道大出血的患者,予以内镜套扎术治疗后,56例使用生长抑素治疗患者设为观察组,88例未使用生长抑素治疗患者设为对照组,比较两组近期再出血发生率。结果:两组初次止血成功率均为100%。144例食管静脉曲张破裂出血患者经EVL治疗后,观察组近期再出血率为23.2%,对照组近期再出血率为6.8%,观察组近期再出血率高于对照组,但比较差异无统计学意义(P>0.05)。结论:EVL联合使用生长抑素对预防食管静脉曲张破裂出血近期再出血可能无优势,提示对轻症病例可不推荐使用生长抑素。

Objective ： To evaluate the efficacy of somatostatin in preventing esophageal variceal rebleeding after endoscopic ligation. Methods： One hundred and forty-four patients with esophageal variceal bleeding treated with endoscopic ligation were enrolled and randomly assigned into treatment group and control group. Patients in treatment group received EVL combined with somatostatin and patients in control group received EVL only. The incidences of rehaemorrhage within 2 weeks were compared. Results： Although the incidence of rehaemorrhage in treatment group was higher than that in control group, there was no significant difference （P 〉 0. 05）. Conclusion： EVL combined with somatostatin doses not reduce incidence of rehaemorrhage in esophageal variceal bleeding. Thus somatostatin is not recommended in patients of well condition.