摘要
目的:探讨血浆一氧化氮(NO)和内皮素(ET)的改变在充血性心力衰竭(CHF)病程中的临床意义。方法:检测35例CHF患者外周静脉血和肺动脉血中NO、ET、血管紧张素转换酶(ACE)的含量。以20例健康体检者作为对照组。结果:CHF患者外周静脉和肺动脉血浆中NO、ET含量显著高于健康对照组(P均<0.05);血浆ACE水平呈现相同的变化;血浆ET增加的幅度大于NO,因此,CHF患者NO/ET比值降低(P<0.05)。这些变化在患者的肺动脉中比外周静脉中更明显(P均<0.05),与心力衰竭的严重程度有关。结论:血浆NO水平增高,NO/ET比值降低是CHF的病理生理特征之一。
Objective:To investigate the clinical significance of changes in plasma nitric oxide (NO) and endothelin (ET) levels in patients with chronic heart failure (CHF).Methods:Using blood samples obtained from vein (V) and pulmonary artery (PA),NO,ET and angiotensinconverting enzyme (ACE) levels were determined in 35 patients with CHF.20 healthy subjects served as normal controls.Results:Plasma NO and ET levels in patients were much higher than those in normal subjects both in V and PA (all P <0 05).Also,plasma ACE levels showed a similar pattern.However,the increase in plasma ET was more obvious thalated to severity of heart failure according to New York Heart Association (NYHA) classification.Conclusions:The increase in plasma NO and decrease in NO/ET ratio might be a pathophysiological characteristic in CHF,which would reflect endothelial dysfunction in CHF.
出处
《中国危重病急救医学》
CAS
CSCD
1999年第1期39-41,共3页
Chinese Critical Care Medicine
关键词
心力衰竭
充血性
一氧化氮
内皮素
ACE
congestive heart failure\ \ nitric oxide\ \ endothelin\ \ angiotensinconverting enzyme