期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白喉毒素催化区结构和活性中心研究进展 被引量：1

Advances on the structure and active center of diphtheria toxin catalytic domain
下载PDF
导出
摘要 自十九世纪末期白喉毒素（diphtheria toxin，DT）被发现以来，它在毒素研究领域一直备受关注，DT的细胞毒性以及其抑制蛋白质合成的性质、穿膜特性等都使DT在近几十年来成为毒素研究的热点，并使其成为了解细菌外毒素作用模式及结构功能关系的一个范例。同时鉴于DT结构与功能的显著特点，白喉毒素已成为导向治疗药物研究中应用最多的细菌毒素。
作者 雷鹏森 曲露 李雅潇
机构地区 武警医学院基础医学部化学教研室 南开大学生命科学学院 武警医学院预防医学系部队卫生学教研室
出处 《武警医学院学报》 CAS 2010年第9期742-745,共4页 Acta Academiae Medicinae CPAPF
关键词 白喉毒素 催化区 X射线衍射 计算机辅助药物分子设计
分类号 R517.3 [医药卫生—内科学]
  • 相关文献

参考文献21

  • 1欧阳晶,王健伟,脱厚珍,洪涛.白喉毒素类免疫毒素研究进展[J].中国生物工程杂志,2003,23(4):36-42. 被引量：12
  • 2Daniele M,Pierluigi P,Giovanni M.Inhibition of adrenocortical carcinoma by diphtheria toxin mutant CRM197[J].Chemotherapy,2009,55(6):425-432.
  • 3Bo HK,Jung-Hwan Y,Sun JM,et al.Enhanced interleukin-2diphtheria toxin conjugate-induced growth suppression in retinoic acid-treated hypoxic hepatocellular carcinoma cells[J].Cancer Let,2009,274(2):259-265.
  • 4Sirisha P,Sanjeeb KS,Rama SV.Targeted therapy of cancer using diphtheria toxin-derived immunotoxins[J].Drug Disc T,2008,13(17-18):807-815.
  • 5Collier RJ,Westbrook EM,McKay DB,et al.X-ray grade crystals of diphtheria toxin[J].J Biol Chem,1982,257:5283-5285.
  • 6Choe S,Bennett M J,Fujii G,et al.The crystal structure of diphtheria toxin[J].Nature,1992,357:216-222.
  • 7Weiss MS,Blanke SR,Collier RJ,et al.Structure of the isolated catalytic domain of diphtheria toxin[J].Biochemistry,1995,34(3):773-781.
  • 8Bell CE,Yeates TO,Eisenberg D.Unusual conformation of nicotinamide adenine dinucleotide(NAD)bound to diphtheria toxin:a comparision with NAD bound to oxidoreductase enzymes[J].Protein Sci,1997,6:2084-2096.
  • 9Jian Q,Karim G,Manuel C.Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity[J].Toxicon,2008,51(3):473-477.
  • 10Silverman JA,Mindell JA,Zhan H,et al.Structure-function relationships in diphtheria toxin ehannels:I.Determining a minimal channel-forming domain[J].J Membr Biol,1994,137(1):17-28.

二级参考文献84

  • 1郭彦伸,褚凤鸣,郭宗儒.距离比较法构建表皮生长因子受体抑制剂的药效团模型[J].中国医学科学院学报,2004,26(4):379-384. 被引量：2
  • 2张新建,李晶,张宝云,洪涛.中国株白喉杆菌白喉毒素全基因编码序列的克隆及其在大肠杆菌中的高效表达[J].中华实验和临床病毒学杂志,1995,9(4):344-348. 被引量：1
  • 3Pang S.Targeting and eradicating cancer cells by a prostate-specific vector carrying the diphtheria toxin A gene. Cancer Gene Ther,2000,7(7) :991 - 996.
  • 4Jin N, Chen W, Blazar BR, et al. Gene therapy of routine solid tumors with T cells transduced with a retroviral vascular endothelial growth factor--immunotoxin target gene. Hum Gene Ther,2002,13(4) :497 - 508.
  • 5Liu YY, Gordienko I,Mathias A,et al. Expressioa. of an anti-CD3 single-chain immunotoxin with a truncated diphtheria toxin in a mutant CHO cell line. Protein Expr Purif,2000,19(2) :304 - 311.
  • 6Knechtle SJ. Treatment with immunotoxin. Philos Trans R Soc Lond B Biol Sci,2001,356(1409) :681 - 689.
  • 7Frankel AE, Kreitman R J, Sausvine EA. Targeted toxins. Clin Cancer Res,2000,6:326 - 334.
  • 8Choe S, Bennett M, Fujii G, et al. The crystal structure of diphtheria toxin. Nature, 1992,357 : 216 - 222.
  • 9Kreitman RJ, Pastan I. Immunotoxins for targeted cancer therapy.Adv Drug Deliv Rey, 1998,31:53 - 88.
  • 10Collier RJ. Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century. Toxicon, 2001,39: 1793 - 1803.

共引文献27

同被引文献9

  • 1Testa U, Riccion R, Biffoni M, et al. Diphtheria toxin fused to variant human inter|eukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression. Blood, 2005, 106: 2527-2529.
  • 2Cohen KA, Liu TF, C|ine JM, et al. Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey. Cancer lmmunol Immunother, 200. 54: 799-806.
  • 3Frankel AE, Ramage J, Kiser M, et al.Characterization of diphtheria fusion proteins targeted to the human interleukin-3 receptor. Protein Eng, 2000, 13: 575-581.
  • 4Shang BY, Huang YH, Zhen YS. Antitumor effect of lidamycin on hepatoma. Chin Rem, 2004, 4: 254-257.
  • 5Xu Y J, Xi Z, Zhen YS, et al. Mechanism of formation of novel covalent drug. DNA interstrand erosslinks and monoadducts by enediyne antitumor antibiotics. Biochemistry, 1997, 36: 14975-14984.
  • 6Liu X, He H, Feng, et al. Diference of cell cycle arrests induced by lidamycin in human breast cancer cells. Anticancer Drugs, 2006, 17: 173-179.
  • 7Liu X, Bian C, Ren K, et al. Lidamycin induces marked G2 cell cycle arest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. Oneol Rep, 2007, 17: 597-603.
  • 8丁晶(综述),宋永平(审校).白血病干细胞研究的最新进展[J].白血病．淋巴瘤,2011,20(7):439-441. 被引量：2
  • 9任思楣,张砚君,彭洪薇,王金宏,纪庆,范冬梅,张楠,曾洁.靶向白血病干细胞CD123的毒性融合蛋白的制备[J].白血病．淋巴瘤,2011,20(8):490-493. 被引量：6

引证文献1

二级引证文献1

武警医学院学报
2010年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部