二甲双胍对多囊卵巢综合征合并高胰岛素血症患者血清胰岛素及性激素的影响

Effect of Metformin on Serum Insulin and Sex Hormone in PCOS with Hyperinsulinemia

目的探讨二甲双胍对多囊卵巢综合征(PCOS)合并高胰岛素血症患者血清胰岛素、性激素及性激素结合球蛋白(SHBG)水平的影响及其作用机制,了解二甲双胍治疗的临床效果。方法给予24例P-COS合并高胰岛素血症患者二甲双胍500 mg,3次/d,治疗8周,对治疗前后血清空腹胰岛素(FINS),胰岛素敏感性指数、性激素及性激素结合蛋白水平进行检测。结果二甲双胍可降低血清空腹胰岛素及睾酮水平(P<0.01),提高胰岛素敏感性指数(P<0.01),治疗前后血清水平差异无显著性(P>0.05)。结论二甲双胍是治疗PCOS的重要手段。

Objective To investigate the effect of metformin on serum insulin,sex hormones and sex hormone-binding globulin（SHBG）level,and to explore the mechanisms in polycystic ovary syndrome（PCOS） with hyperinsulinemia.Methods Twenty-four PCOS women with hyperinsulinemia participated in the study and were administered with metformin at a dose of 500 mg three times a day for 8 weeks.Serum insulin and sex hormones were detected before and then after a 8 week metformin therapy.Results Metformin induced a significant decrease in serum insulin and testosterone levels（P0.01）.It also led to an increase in insulin sensitivity index（P0.01）.No significant difference in serum SHBG were observed after metformin therapy（P0.05）.Conclusion Metformin can decrease serum insulin and testosterone levels,improve the micro-environment of ovary,thus metformin is an important therapy for PCOS.