高渗盐水治疗外伤性颅内高压的疗效观察

Hypertonic Saline Treatment of Traumatic Intracranial Hypertension

目的:观察高渗盐水治疗外伤性颅内高压的疗效。方法:将49例颅脑外伤后出现颅内压增高的患者随机分为两组:高渗盐水组25例,给予3%氯化钠;甘露醇组24例,给予20%甘露醇;均用250ml静脉快速滴注。连续监测患者的颅内压,记录起效时间、以及治疗后至颅内压回复到用药前水平所间隔的时间。结果:高渗盐水和甘露醇均可显著降低颅内压,高渗盐水作用持续时间较甘露醇长(P<0.05)。结论:高渗盐水可用于治疗外伤性颅内高压。

Objective：Observation of hypertonie saline treatment of traumatic intracranial hypertension efficacy.Methods：49 cases of traumatic brain injury will be after the patients with intracranial hypertension were randomly divided into two groups：25 cases of hypertonic saline group to give 3% sodium chloride;mannitol group of 24 patients given 20% mannitol.Were used the rapid intravenous infusion of 250ml. Continuous monitoring of intracranial pressure in patients with recorded onset time,as well as the intracranial pressure after treatment to return to the level of drug use before the time interval.Results：Hypertonic saline and marmitol may reduce intracranial pressure significantly,the role of hypertonic saline lasted longer than mannitol （P〈0.05）.Conclusion：Hypertonic saline can be used for traumatic intracranial hypertension.