重组人碱性成纤维细胞生长因子(bFGF)促进海水浸泡兔软组织创伤愈合的实验研究

Effect of bFGF on Promoting Rehabilition of the Seawater Immersion Wound in Animals

目的:观察了解重组人碱性成纤维细胞生长因子(bFGF)对海水浸泡后的兔软组织创伤的治疗效果。方法:以成年家兔为实验动物,建立背部双侧圆形创伤模型,每组8只,随机分为单纯创伤组(对照组)、创伤合并海水浸泡组(海水浸泡组)、创伤合并海水浸泡后重组人bFGF治疗组(bFGF组)。观察各组创面肉芽组织的生长状况,统计创面面积变化及创面愈合。结果:海水浸泡组的肉芽组织形成时间显著晚于对照组及bFGF组。对照组平均愈合时间为(12.4±0.9)d;创伤合并海水浸泡组的平均愈合时间为(16.9±1.1)d;海水浸泡合并碱性成纤维细胞生长因子治疗组的平均愈合时间为(13.5±1.1)d。结论:海水浸泡能导致伤口愈合时间延迟,bFGF对于海水浸泡伤口具有显著促愈合作用。

Objective：To study the effect of＇bFGF on promoting rehabilitiong of the seawater immersion wound in rabbits. Methods： The wound models on skin of rabbits were made and randomly divided into three groups, which were control group, seawater immersion group and bFGF treatment group, the immersion time is 20 minutes. Each group had 8 rabbits. The growth of wound granulation was observed, and wound areas were recorded by photos and ruler measurement. Results：The mean healing time of the wounds in control group was （12.4±0.9）d; （16.9±1.1）d when treated by seawater immersion; and （13.5±1.1）d when treated by bFGF after seawater immersion. Conclusion：These findings suggest that wound healing can be delayed by seawater immersion. And bFGF could promoting rehabilition the healing time of the seawater immersion wound.