摘要
目的:探讨全麻对脑胶质细胞瘤开颅手术病人白细胞介素2(IL-2)和可溶性白细胞介素-2受体(slL-2R)的影响意义。方法:选择天坛医院神经外科择期脑胶质细胞瘤开颅切除术病人22例。检测麻醉前,麻醉诱导后,手术结束时,术后2h的血清IL-2及slL-2R浓度。结果:IL-2浓度在麻醉诱导后、手术结束时和术后2h均较麻醉前明显降低(P<0.05)。麻醉诱导后sIL-2R浓度与麻醉前无明显变化,手术结束时和术后2b的slL-2R浓度明显低于麻醉前(p<0.05)。结论:麻醉与手术对脑胶质细胞瘤病人免疫功能均有进一步影响。
Objective：To observe the influence of general anesthesia to serum interleukin-2 （IL-2） and soluble intedeukin-2 receptor （sIL- 2R） in patients with cerebral gtioma craniotomy.Methods：In 22 cerebral glioma craniotomy patients,serum IL-2 and sIL-2R were measured before anesthesia, after induction of anesthesia,at the end of operation,and at the 2h after operation.Results：Serum IL-2 concentration decreased significantly after induction of anesthesia,at the end of operation and at the 2h after operation than IL-2 level before anesthesia（P〈0.05）.Serum sIL-2R concentration after induction of anesthesia had no difference with sIL-2R level before anesthesia.Serum sIL-2R concentration at the end of operation and 2h after operation decreased significantly than sIL-2R level before anesthesia（P〈0,05）.Conelusion：Anesthesia and operation had influence on immune functions of patients with cerebral glioma.
出处
《中国医药导刊》
2010年第7期1136-1137,共2页
Chinese Journal of Medicinal Guide
